Glauco Masetti was born on April 19, 1922 in Milan, Italy and was an autodidact on reed instruments as well as a classically trained violinist, attending the Milan and Turin conservatories.
In the late 1940s he worked with Gil Cuppini for the first time, an association that would continue well into the latter part of the 1960s. He worked often as a session musician in the first half of the 1950s, with Gianni Basso and Oscar Valdambrini among others.
He led his own ensemble from 1955, and played with Eraldo Volonté and Chet Baker. In the Sixties, he also played with Giorgio Gaslini during that decade. Clarinetist and alto saxophonist Glauco Masetti passed away on May 27, 2001 in Milan.